Experts Examine the True Health Effects of
Mold and Fungi

Recently, a group of leading experts gathered to distinguish fact from fiction when it comes to how mold effects our health. The experts reviewed recent scientific evidence on health effects of mold at the Annual Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Anaheim.

Majority of Fungi is Not Allergenic
“ Fungi, including molds, are spore-producing organisms that comprise some 25 percent of the earth’s biomass and function as decomposers of organic material,” said Richard W. Weber, National Jewish Medicine & Research Center in Denver. “Only about 80 of the 1.5 million species of fungi are known to be allergenic.

It is rather surprising that only a small percentage of the millions of species of fungi are actually allergenic. Dr. Weber continued, “The most common fungi found in homes include Cladosporium, Aspergillus, Penicillium, Alternaria, basidiospores, Chaetomium, Periconia and Stachybotrys. Indoor levels of airborne fungi are generally below outdoor levels of similar species in a well-constructed home without water damage. We have found 30 percent to 70 percent of recovered indoor spores come from outside sources.”

Health Effects of Fungi Exposure
About 10 percent of the U.S. population is sensitive to fungi. Fungi can cause a number of well-know health effects including infections and respiratory problems (sinusitis, asthma). Perhaps less well known example of fungi effecting health can be seen in a 1991 study published in The New England Journal of Medicine that found that asthmatics sensitive to Alternaria fungi faced a 200-fold risk for respiratory arrest.

“Well-known health effects caused by exposure to fungi include infections, toxins and hypersensitivity diseases including asthma, rhinitis, hypersensitivity pneumonitis and allergic bronchopulmonary aspergillosis (fungal infection of the lungs),” said Robert K. Bush, M.D., University of Wisconsin in Madison.

“Sensitivity to fungi is prevalent in asthmatics, and those who are sensitive are at risk for severe, potentially life-threatening asthma. Increased outdoor fungal spore counts have been associated with increased asthma emergency department visits and hospitalization,” Dr. Bush said.

Allergy Shots May Help Control Mold Sensitivity
Not only can allergy shots help with pollen and grass allergies, but also they may help patients who are sensitive to mold spores. Immunotherapy, or allergy shots, has been effective in several double-blind, placebo-controlled trials in mold sensitive patients. But the availability of these shots is limited for those with fungi or mold allergies.

“Although there are hundreds of thousands of species of fungi, allergen extract availability is limited to a relatively small number of fungi including the two most prevalent outdoor fungi, Alternaria and Cladosporium,” said Harold S. Nelson, M.D., National Jewish Medical and Research Center in Denver. “Immunotherapy should be limited to those patients with documented sensitivity to fungus, whose symptoms occur during periods of high atmospheric exposure to that fungus, and environmental control is not possible.”

Risks of Toxic Mold Syndrome
Many have heard about possible toxic mold, but does toxic mold syndrome really exist? The medical experts also examined this topic and research done regarding toxic mold. Toxic mold syndrome or inhalational toxicity continues to cause public concern despite a lack of scientific evidence that supports its existence said Emil J. Bardana, Jr., M.D., Oregon Health & Science University in Portland, Ore.

In a recent study published in Annals of Allergy, Asthma & Immunology, the scientific journal of the ACAAI, investigators at the Oregon Health & Science University conducted a retrospective review of 50 individuals who claimed compensation for toxic mold disease, and in every case found alternative medical and/or psychiatric explanations for the claimed illness.

Investigators found only two of the 50 subjects had evidence of mold-related allergic disease attributable to their home or workplace. Seventeen individuals complained of a nonspecific irritant symptoms complex that could not be linked to mold exposure. These symptoms included headache, irritability, cognitive impairment and fatigue.

“Based on our findings, no case definition is possible for so-called ‘toxic mold syndrome,’” said Dr. Bardana, co-author of the report. “Fungal contamination of a residence does not necessarily constitute an abnormal exposure. The presence of fungal allergen sensitivity proves prior exposure, but not necessarily a symptomatic state.

“Because molds are encountered both indoors and outdoors, it is almost impossible to determine where the sensitivity arose. Specific toxicity due to inhaled molds, including the role of Stachybotrys in building-related illness, has not been scientifically established by any published study,” he said.

Fear of Mold Can Have Psychological Effects
“ Some people believe that anything with the word ‘toxin’ in it must be very dangerous,” said David D. Fox, Ph.D., Glendale, Calif. “Some individuals tend to focus on their symptoms and attribute all of their problems to mold exposure, downplaying other causes.”

Molds typically cited as causing psychological or cognitive problems are Stachybotrys chartarum, Aspergillus, Fusarium and Penicillium. Symptoms of a physical nature may include sleep deprivation, loss of appetite, fatigue, headaches, dizziness, vague aches and pains and respiratory problems. Psychological and cognitive symptoms are also attributed to toxic mold, including irritability, panic, anxiety, poor concentration and confusion.

“It is a normal psychological need to have an explanation for symptoms. Many people show psychological or cognitive symptoms that are exacerbated when their health is potentially threatened. Pre-existing psychological disorders and misinformation from media, friends and even doctors can play a role in causing symptoms,” said Dr. Fox

How Can Mold Sensitive People Take Control?
Although indoor mold is prevalent in all homes, there are steps that mold-sensitive individuals can take to control indoor mold contamination, helping to lessen the effect mold has on allergies and sinus suffering.

“The first step toward preventing indoor mold is to stop leaks, minimize condensation, and keep relative humidity low,” said Jay M. Portnoy, M.D., Children’s Mercy Hospital in Kansas City, Mo. “Dehumidifiers, proper ventilation, and control of air flow and air pressure can help reduce indoor mold growth. Bleach solutions are recommended for removing mold on nonporous surfaces. Porous surfaces may require removal and replacement of materials if mold contamination is extensive.”

In a study conducted by Dr. Portnoy and his colleagues published 2001 in Aerobiologia, mold spore counts were found to be highest in the laundry room (11,424), bathroom (8,540) and unfinished basement (6,694) in a sampling of 241 rooms.

“If a patient who is sensitive to mold is exposed to substantial mold in their environment, it may be determined that there is evidence of a relationship between mold exposure and symptoms. An environmental assessment may be important if health effects are associated with the home or building and there is structural damage and aesthetic problems, including odor,” said Dr. Portnoy.

“We would want to look at the family history of allergic disease and find out if the symptoms are associated with specific activities or events. The history of the home or building, its occupancy and its environmental characteristics would be evaluated. Fungal exposure can be measured by collection and analysis of house dust if validated methods are used,” he said.

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